Dynamics of unfolded protein response in recombinant CHO cells
نویسندگان
چکیده
منابع مشابه
Systems biology of unfolded protein response in recombinant CHO cells
Background Productivity of recombinant therapeutics is a coordinated effort of multiple pathways in the cell [1]. The protein processing pathway in endoplasmic reticulum has been the target of many cell engineering studies but with mixed results [2]. We have observed the induction of UPR genes in recombinant CHO cells (data not shown). In this work, we attempt to increase their productivity fur...
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ژورنال
عنوان ژورنال: Cytotechnology
سال: 2014
ISSN: 0920-9069,1573-0778
DOI: 10.1007/s10616-013-9678-8